A 75-year-old male with a 30-year history of ulcerative colitis requiring long-term oral corticosteroid therapy presented with a 6-month history of persistent headaches and gait disturbance. Brain magnetic resonance imaging (MRI) demonstrated diffuse pachymeningeal enhancement and thickening along the bilateral cerebral convexities (Fig. 1A, B). Cerebrospinal fluid analysis revealed a normal white blood cell count (0 cells/μL), but markedly elevated protein levels (167.3 mg/dL) and an increased immunoglobulin G index (0.75). A vasculitis panel was all negative. Testing for myelin oligodendrocyte glycoprotein (MOG) antibodies revealed positivity with an mean fluorescence intensity ratio of 4.00 (positive threshold >3.65). Finally, the patient was diagnosed with MOG antibody-associated disease (MOGAD) presenting as pachymeningitis. After treatment with oral prednisolone and azathioprine, the patient demonstrated gradual clinical improvement, and the follow-up brain MRI after 3 months of treatment showed significant resolution of the pachymeningitis (Fig. 1C, D). Clinicians should be mindful that MOGAD can present with a wide variety of clinical manifestations, including pachymeningitis.1,2