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Review Article
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J Mult Scler. 2012;3(1):1-5. Published online March 1, 2012.
- 아토피척수염: 새로운 질환인가?
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주인수, 주인수
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아주대학교 의과대학 신경과학교실
아주대학교 의과대학 신경과학교실 -
- Atopic Myelitis: A New Disease Entity?
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In Soo Joo, In Soo Joo
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Department of Neurology, Ajou University School of Medicine, Suwon, Korea
Department of Neurology, Ajou University School of Medicine, Suwon, Korea -
- Abstract
- "Atopic myelitis (AM) is one of idiopathic myelitis that has mostly been reported in Far East countries including Korea and Japan. A significant relationship between AM and both hyperIgEaemia andspecific antibodies to house dust mice has been found. The AM patients show relativelyhomogenous clinical manifestations, laboratory findings,and radiological features (1) a preferentialinvolvement of the cervical or thoracic cord, (2) predominant sensory symptoms, (3) low EDSSscore, (4) relatively long lesion more than 3 vertebral segments with normal CSF findings includingIgG index or oligoclonal band, (5) a negative serum anti-aquaporin 4 antibody, and (6) normal brainMRI. In addition, they have increased eosinophils in peripheral blood. These findings suggest thatAM might be a distinctive disease entity not associated with multiple sclerosis or neuromyelitisoptica. The exact pathogenetic mechanisms of AM are still unresolved. A recent study reported thatIgG antibody specific to Toxocara canis was frequently positive in the serum of AM patients,suggesting the possibility that toxocariasis might be another cause of AM. High-dose steroid pulsetherapy and/or plasma exchanges are the mainstay treatment for AM as well as other idiopathicmyelitis.Journal of Multiple Sclerosis 3(1):1-5, 2012"
Keywords :Atopic myelitis, HyperIgEaemia, Toxocariasis
