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Review Article
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J Mult Scler. 2018;9(1):1-6. Published online March 1, 2018.
- 수초희소돌기아교세포당단백질 항체 연관 중추신경염증질환
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류성근, 박민수
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영남대학교 의과대학 신경과학교실
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- Myelin Oligodendrocyte Glycoprotein Immunoglobulin-G Associated Central Nervous System Inflammatory Disorder
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Seong Geun Ryu, Min Su Park
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Department of Neurology, Yeungnam University College of Medicine, Daegu, Korea
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- Abstract
- "Autoantibody against myelin oligodendrocyte glycoprotein (MOG) has been recently recognized as a new inflammatory disease entity distinct from multiple sclerosis (MS) and aquaporin-4 (AQP4) antibodypositive neuromyelitis optica spectrum disorder (NMOSD). MOG autoantibody may cause oligodendrocytedamage and myelin dysfunction without astrocytopathy. MOG-immunoglobulin G(IgG) is detected in 4-10% of central nervous system (CNS) inflammatory demyelinating disordersthat include MS, NMOSD, acute disseminated encephalomyelitis (ADEM), idiopathic optic neuritisand idiopathic acute transverse myelitis. MOG-IgG disease affects female slightly more than male.The most common clinical phenotype is optic neuritis followed by myelitis, brainstem symptoms,ADEM like presentation and multifocal involvement. About 50-80% of MOG-IgG disease have relapsingdisease course and relapsing optic neuritis is the most common clinical syndrome. Acutetreatment and long term maintenance therapy are needed in MOG-IgG disease. Prognosis inMOG-IgG disease has more favorable outcome than AQP4 antibody positive NMOSD.Journal of Multiple Sclerosis 9(1):1-6, 2018"
Keywords :Myelin oligodendrocyte glycoprotein, Neuromyelitis optica spectrum disorder, Aquaporin 4
