| 자가면역질환의 발병기전 및 치료에서의 T세포관용의 역할 |
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최경호 |
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서울대학교 의과대학 생화학교실/의과학과 |
| The Role of T Cell Tolerance in the Pathogenesis and Treatment of Autoimmune Diseases |
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Kyungho Choi |
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Department of Biochemistry and Molecular Biology and Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea |
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| Abstract |
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"Many of Autoimmune diseases are caused by hyperactivation of autoreactive T cells. Therefore,immunosuppressive pharmaceuticals have been widely used for treatment of autoimmunediseases. However, general suppression of immune system can elicit adverse side effects such asopportunistic infections and cancers. Thus, the long-lasting, specific inhibition of pathogenic T cellsfollowing short-term treatment will be an ideal way of treating these chronic diseases. Physiologicallyautoreactive T cells are effectively controlled by antigen-specific long-term inhibitory machinerycalled T cell tolerance. Hence, T cell tolerance induction therapy in established autoimmune diseasessuch as type 1 diabetes and rheumatoid arthritis are actively investigated both experimentally and inclinic. In this review, I will discuss the basic mechanism of T cell tolerance and theoretical frameworkof translating these concepts to clinical therapeutics. Journal of Multiple Sclerosis 4(1):13-18, 2013" |
| Key Words:
T cell tolerance, Autoimmune diseases, Two signal hypothesis, T cell anergy, Regulatory |
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