| 아토피척수염: 새로운 질환인가? |
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주인수, 주인수 |
아주대학교 의과대학 신경과학교실
아주대학교 의과대학 신경과학교실 |
| Atopic Myelitis: A New Disease Entity? |
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In Soo Joo, In Soo Joo |
Department of Neurology, Ajou University School of Medicine, Suwon, Korea
Department of Neurology, Ajou University School of Medicine, Suwon, Korea |
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| Abstract |
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"Atopic myelitis (AM) is one of idiopathic myelitis that has mostly been reported in Far East countries including Korea and Japan. A significant relationship between AM and both hyperIgEaemia andspecific antibodies to house dust mice has been found. The AM patients show relativelyhomogenous clinical manifestations, laboratory findings,and radiological features (1) a preferentialinvolvement of the cervical or thoracic cord, (2) predominant sensory symptoms, (3) low EDSSscore, (4) relatively long lesion more than 3 vertebral segments with normal CSF findings includingIgG index or oligoclonal band, (5) a negative serum anti-aquaporin 4 antibody, and (6) normal brainMRI. In addition, they have increased eosinophils in peripheral blood. These findings suggest thatAM might be a distinctive disease entity not associated with multiple sclerosis or neuromyelitisoptica. The exact pathogenetic mechanisms of AM are still unresolved. A recent study reported thatIgG antibody specific to Toxocara canis was frequently positive in the serum of AM patients,suggesting the possibility that toxocariasis might be another cause of AM. High-dose steroid pulsetherapy and/or plasma exchanges are the mainstay treatment for AM as well as other idiopathicmyelitis.Journal of Multiple Sclerosis 3(1):1-5, 2012" |
| Key Words:
Atopic myelitis, HyperIgEaemia, Toxocariasis |
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