| 급성 척수염 환자에서의 예후: 단일 기관 후향적 연구 |
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김지선, 김지선, 장재홍, 장재홍 |
고려대학교 의과대학 신경과학교실
고려대학교 의과대학 신경과학교실 |
| Prognosis of Patients with Acute Myelitis; A Single Hospital-based Retrospective Analysis |
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Ji-Sun Kim, Ji-Sun Kim, Jae Hong Jang, Jae Hong Jang |
Department of Neurology, Korea University Medical Center, Seoul, Korea
Department of Neurology, Korea University Medical Center, Seoul, Korea |
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| Abstract |
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"Acute myelitis (AM) may be the initial presentation of multiple sclerosis (MS) or neuromyelitisoptica (NMO). Therefore, predicting conversion risk to MS or NMO is one of many key considerations in themanagement of patients with AM. To identify the clinical and laboratory variables in patients withfirst-ever AM that predict relapses or conversion to NMO or MS. We selected patients who met thefollowing criteria; (1) patients who were visited to our hospital for myelitis as first-ever inflammatorydisorders in central nervous system from May 2006 to April 2011, (2) at least 24 months follow-upafter onset of symptoms. We reviewed medical records to recruit data related to demographics,clinical features, and ancillary tests. The prognostic values of all variables were analyzed forconversion to MS or NMO. Of 31 patients with AM, 5 patients (mean age 32.6 years) converted toMS (3 women) or NMO (2 women), and 26 (18 men and 8 women, mean age 45.0 years) remainedmonophasic. Mean follow-up time was 6.1 years. Female gender (p = 0.008) and dissemination inspace on MRI by MAGNIMS criteria (p = 0.029) were associated with conversion to MS orNMO.There were no significant differences in age of onset, clinical characteristics, CSF findings,spinal MRI or evoked potentials between two subgroups. Brain lesions and being female with AMmay be risk factors in the development of MS or NMO. Journal of Multiple Sclerosis 3(1):20-25, 2012" |
| Key Words:
Acute myelitis, Multiple sclerosis, Neuromyelitis optica |
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