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Overview of Rheumatologic Diseases Associated with Central Nervous System Involvement: Focusing on Sj?gren’s Syndrome, Antiphospholipid Antibody Syndrome, and Behcet’s Disease

J Mult Scler > Volume 3(2); 2012 > Article
Journal of Multiple Sclerosis 2012;3(2):38-46.
Published online September 1, 2012.
중추신경계 침범과 관련한 류마티스 질환의 이해: 쇼그렌증후군, 항인지질항체 증후군, 베체트병을 중심으로
안중경, 안중경
성균관대학교 의과대학 내과학교실, 강북삼성병원 내과
성균관대학교 의과대학 내과학교실,
강북삼성병원 내과
Overview of Rheumatologic Diseases Associated with Central Nervous System Involvement: Focusing on Sj?gren’s Syndrome, Antiphospholipid Antibody Syndrome, and Behcet’s Disease
Joong Kyong Ahn, Joong Kyong Ahn
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea
Abstract
"Systemic rheumatic diseases may have present with several neurologic manifestations. Central nervous manifestations certainly occur in various rheumatic diseases including systemic lupuserythematosus, Sj?gren’s syndrome. Neurologic manifestations in rheumatic diseases can be indistinguishablefrom an inflammatory demyelinating disease of the central nervous system (CNS) suchas multiple sclerosis and neuromyelitis optica because of strikingly similar manifestations and nospecific diagnostic tools. However, it is important to make differential diagnosis between rheumaticdiseases with neurologic involvement and inflammatory CNS demyelinating diseases because ofquite different treatment and prognosis. Thus, assessment for systemic rheumatic diseases shouldbe included in all patients presenting with CNS demyelinating disease, and vice versa. We discusshere the clinical features, pathogenic mechanisms, laboratory findings and diagnosis of systemicrheumatic diseases associated with CNS involvement, focusing on Sj?gren’s syndrome, antiphospholipidantibody syndrome and Behcet’s disease. Journal of Multiple Sclerosis 3(2):38-46, 2012"
Key Words: Sj?gren’s syndrome, Antiphospholipid antibody syndrome, Behcet’s disease, Neurologic
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