| 전국적 규모의 전향적 다발성경화증 등록 체계의 설립: 제1단계 임상 자료의 중간 보고 |
|
권오현, 김호진, 김병준, 박민수, 김병조, 민주홍, 이광수, 안재영, 김광국, 임영민, 천상명, 김승민, 이상수, 홍윤호, 김선영, 박만석, 신병수, 배종석, 김종국, 이광호 |
을지대학교 의과대학 신경과학교실
국립암센터 임상지원센터 및 다발성경화증 클리닉
성균관대학교 의과대학 신경과학교실 |
| The Prospective Nation-wide Multiple Sclerosis Registry: Interim Analysis of Clinical Data |
|
Ohyun Kwon, Ho Jin Kim, Byung-Joon Kim, Min Su Park, Byung-Jo Kim, Joo-Hong Min, Kwang-Soo Lee, Jae-Young An, Kwang-Kuk Kim, Young-Min Lim, Sang-Myung Cheon, Seung Min Kim, Sang-Soo Lee, Yoon-Ho Hong, Sun-Young Kim, Man-Seok Park, Byoung-Soo Shin, Jong-Seok Bae, Jong-Kuk Kim, Kwang Ho Lee |
Department of Neurology, Eulji University College of Medicine, Seoul
Center for Clinical Supports and Multiple Sclerosis Clinic, National Cancer Center, Goyang
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Daegu |
|
|
| Abstract |
|
"The changing nosological concept of so-called opticospinal multiple sclerosis (MS) into relapsing neuromyelitis optica (NMO) and the advent of disease-modifying therapy of MS cast the urgent need of epidemiological status of MS and related disorders in Korea. To meet this need, Nation-wide Multiple Sclerosis Registry was set off in 2008. The subject of disorders includes clinically isolated syndrome (CIS), MS, NMO, acute disseminated encephalomyelopathy, and other autoimmune CNS inflammatory disease and the 20 participating hospitals were covered most of geographical territory of Korea. The Registry collected the comprehensive data of patients regarding not only clinical data,but also electrophysiological data, relevant MRI, and serum. Total of 363 patients were enrolled over two years (M:F=1:2.1, onset age, 34.5±12.5 years, disease duration, 4.5±7.0 years). The relative disease distribution of the pool of the first year’s restrospective enrollment (138 patients) was as follows: MS in 59.4%, NMO in 27.5%, recurrent monosymptomatic diseases in 3.6%, and CIS in 5.1%. In contrast, that of the prospective second year’s one (225 patients) showed that the relative proportion of NMO (28.8%) was comparable to that of MS (29.2%) and that patients with recurrent monosymptomatic diseases (16.5%) and CIS (20.3%) comprised a third of the pool. This study shows for the first time that NMO is at least half as frequent as MS in Korea. Further enrollment and longitudinal tracking of the patients as well as radiological and serological data would refine the epidemiological findings and also be a step stone in establishing the clinical guideline of diagnosis and management of CNS demyelinating disorders in Korea. Journal of Multiple Sclerosis 1(2):52-58, 2010" |
| Key Words:
CNS demyelinating autoimmune diseases, Epidemiology, Multiple sclerosis, Neuromyelitis optica |
|
PDF Links
Download Citation
