| GM1, GD1a 항체 양성인 횡단성척수염과 병발한 급성운동축삭신경병의 임상적 증상과 예후 |
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김아영1, 유홍근1, 전종현1, 권혁성2 |
1한양대학교 의과대학 신경과
2한양대학교 의과대학 한양대학교 구리병원 신경과 |
| Clinical Manifestation and Prognosis of Overlapping Acute Motor Axonal Neuropathy and Acute Transverse Myelitis with Anti-GM1 and Anti-GD1a Antibodies: A Case Study |
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A Young Kim1, Hong Keun Yoo1, Jong Hyun Jeon1, Hyuk Sung Kwon2 |
1Department of Neurology, Hanyang University College of Medicine, Seoul, Korea
2Department of Neurology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea |
Correspondence:
Hyuk Sung Kwon, Tel: +82-31-560-2260, Fax: +82-31-560-2289,
Email: kwonhs@hanyang.ac.kr
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Received: 12 February 2025 • Revised: 11 March 2025 • Accepted: 7 April 2025 |
| Abstract |
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Antibodies against GM1 and GD1a are closely associated with acute motor axonal neuropathy (AMAN). Patients simultaneously positive for both anti-GM1 and anti-GD1a antibodies are rare, and their clinical manifestations and prognosis remain unclear. Herein we report a 41-year-old male diagnosed with AMAN and acute transverse myelitis who was positive for immunoglobulin M anti-GM1, immunoglobulin G (IgG) anti-GM1, and IgG anti-GD1a antibodies. He experienced rapid progression of motor weakness to near quadriplegia within a few days, followed by substantial improvement over 6 months after initiation of steroid treatment, resulting in return of most activities of daily living. |
| Key Words:
Antibodies against GM1, GD1a, Acute transverse myelitis, Guillain-Barre syndrome |
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