| 인터페론 베타 치료를 받은 한국 다발성경화증 환자에서의 |
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현재원, 공병수, 정애란, 정인혜, 김수현, 김호진 |
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국립암센터 신경과 |
| Neutralizing Antibodies in Korean Multiple Sclerosis Patients Treated with Interferon-Beta: Preliminary Study |
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Jae-Won Hyun, Byungsoo Kong, AeRan Joung, In Hye Jeong, Su-Hyun Kim, Ho Jin Kim |
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Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Korea |
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| Abstract |
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"Background: Patients treated with interferon-beta (IFN-β) can develop neutralizing antibodies (NAB) against IFN-β, which negatively affect its therapeutic responses. We aimed to investigate prevalenceof NAB and to evaluate the impact of NAB on the treatment response of IFN-β in Korean patientswith multiple sclerosis (MS).Methods: This was a single center, retrospective study of MS patients treated with subcutaneousIFN-β-1a and IFN-β-1b in Korea. Patients with MS who were treated with IFN-β at least for 6 monthswere enrolled. Sera, which were not influenced by acute treatment for MS, were tested for NAB usingthe luciferase reporter gene assay.Results: A total of 96 MS patients were enrolled. NAB were found in 28 (29%) patients at the singletest; 23 of 66 (35%) patients treated with subcutaneous IFN-β-1b and 5 of 30 (17%) patients treatedwith subcutaneous IFN-β-1a. The frequency of NAB positivity was highest (n＝18, 39%) in patientstreated with IFN-β for 12 to 24 months. Until now, 20 of 28 patients with NAB were tested at two differenttime points to confirm the persistent positivity of NAB. Of 20 patients with NAB at the singletest, 11 patients showed persistent positivity of NAB and 8 of them (73%) revealed disease activitybefore and after 6 months of NAB positivity. In contrast, 3 of 9 patients (33%) who showed transientpositivity of NAB showed disease activity.Conclusions: The current study is ongoing to confirm the clinical implication of persistent positivityand titers of NAB in the multi-center cohort. Journal of Multiple Sclerosis 7(1):9-13, 2016" |
| Key Words:
Multiple sclerosis, Neutralizing antibody, Disease modifying treatment |
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