Recent Clinical Trials of Multiple Sclerosis

An, Jae Young; Lee, Kwang Soo

J Mult Scler > Volume 1(1); 2010 > Article

Review Article

Journal of Multiple Sclerosis 2010;1(1):6-11.
Published online March 1, 2010.

다발성 경화증의 최근 임상시험

안재영, 이광수

가톨릭대학교 의과대학 신경과학교실

Recent Clinical Trials of Multiple Sclerosis

Jae Young An, Kwang Soo Lee

Department of Neurology, The Catholic University of Korea College of Medicine, Seoul, Korea

Abstract

"The immunopathogenesis of multiple sclerosis has been broadened during the past decade and a number of new strategies were developed for the treatment of the disease. Six pharmacological agents are currently approved for the treatment of multiple sclerosis. However, these drugs are only partially effective and patients may still encounter relapses, disease progression or adverse effects. A sizable number of new agents and optimizing current therapies such as various combination regimens are under investigation currently. However, with availability of newer therapies, the choice of a first-line agent will become more complicated with risk-to-benefit ratios playing a major role in the decision making process. Journal of Multiple Sclerosis 1(1):6-11, 2010"

Key Words: Multiple sclerosis, interferon-β, glatiramer acetate, cladribine, fingolimod, monoclonal antibody