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Clinical Practice Guideline of Clinically Isolated Syndrome: Part II. Management and Monitoring

J Mult Scler > Volume 7(2); 2016 > Article
Journal of Multiple Sclerosis 2016;7(2):40-48.
Published online September 1, 2016.
임상적단독증후군의 임상진료지침: 2부. 관리와 추적
오지영1, 조중양2, 강사윤3, 김남희4, 김선영5, 김성민6, 김수현7, 김지영8, 남태승9, 박민수10, 신하영11, 조정희12, 허소영13, 김우준14, 민주홍15, 권오현16
1건국대학교 의학전문대학원 건국대학교병원 신경과학교실
2인제대학교 의과대학 일산백병원 신경과학교실
3제주대학교 의과대학 제주대학 교병원 신경과학교실
Clinical Practice Guideline of Clinically Isolated Syndrome: Part II. Management and Monitoring
Jeeyoung Oh1, Joong-Yang Cho2, Sa Yoon Kang3, Nam-Hee Kim4, Sun-Young Kim5, Sung-Min Kim6, Su-Hyun Kim7, Jee Young Kim8, Tai-seung Nam9, Min Su Park10, Ha Young Shin11, Jung Hee Cho12, So-Young Huh13, Woojun Kim14, Ju-Hong Min15, Ohyun Kwon16
1Department of Neurology, Kunkuk University Hospital, Kunkuk University School of Medicine
2Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine
3Department of Neurology, Jeju National University Hospital, Jeju University College of Medicine
Abstract
"Clinically isolated syndrome (CIS) is the typical first clinical episode that is highly suggestive of multiple sclerosis (MS). Without diagnostic marker, diagnosing CIS is exactly alike diagnosing MS witheven less evidences and requires careful and integrative interpretation of clinical, radiological andimmunological findings. In the aspect of management, numerous clinical trials and cohort studiesstrongly support prompt start of disease modifying therapies even in the stage of CIS to prevent disabilityaccumulation with disease activity. This guideline covers sequential stages of clinical practice- encounter, assessment, diagnosis, and management - and addresses their principal evidences tohelp clinicians make correct diagnosis and proper management. Though it cannot be emphasizedtoo much to consider every possible differential diagnosis other than MS thoroughly when we encounterpatients with CIS, the details regarding differential diagnosis are out of the scope of thisguideline. The guideline would be regularly updated and revised every a few years to serve its role. Journal of Multiple Sclerosis 7(2):40-48, 2016"
Key Words: Clinically isolated syndrome, Management, Monitoring, Guideline


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