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Neuromyelitis Optica: What’s New in 2011-2012?
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J Mult Scler > Volume 3(2); 2012 > Article
Review Article
Journal of Multiple Sclerosis 2012;3(2):33-37.
Published online September 1, 2012.
시신경척수염: 최신지견
신하영, 신하영
연세대학교 의과대학 신경과학교실
연세대학교 의과대학 신경과학교실
Neuromyelitis Optica: What’s New in 2011-2012?
Ha Young Shin, Ha Young Shin
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea
Abstract
"Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system, which affects optic nerve and spinal cord preferentially. After the discovery of NMO-IgG in patientsof NMO and the identification of aquaporin 4 as a target of NMO-IgG, the knowledge aboutNMO is growing explosively. Advances in our understanding of the patho-mechanism of NMO haveidentified new targets for future therapeutic efforts, including anti-aquaporin-4 monoclonal antibodyblocker and neutrophil protease inhibition. This review highlights the recent advances in currenttreatment and future therapeutic approaches. Journal of Multiple Sclerosis 3(2):33-37, 2012"
Key Words: Neuromyelitis optica, Devic’s disease, Anti-Aquaporin-4 antibody
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