What’s New in Neuromyelitis Optica: 2012-2013

Kim, Woojun; Kim, Woojun

J Mult Scler > Volume 5(1); 2014 > Article

Review Article

Journal of Multiple Sclerosis 2014;5(1):7-13.
Published online March 1, 2014.

시신경척수염의 최신지견: 2012-2013년

김우준, 김우준

가톨릭대학교 의과대학 신경과학교실
가톨릭대학교 의과대학 신경과학교실

What’s New in Neuromyelitis Optica: 2012-2013

Woojun Kim, Woojun Kim

Department of Neurology, The Catholic University of Korea School of Medicine, Seoul, Korea
Department of Neurology, The Catholic University of Korea School of Medicine, Seoul, Korea

Abstract

"Since the discovery of specific antibody against aquaporin-4 (AQP4-Ab), the concept of the neuromyelitis optica (NMO) has been changed, and new findings about the disease have been exploded.This review covers clinical, pathological, immunological, and imaging studies published between2012 and early 2013 that presented new findings on NMO. New rolls of AQP4-Abs, natural killercells, cytotoxic T cells, eosinophils, and high-mobility group box 1 in the pathogenesis of NMO werepresented. Studies using various imaging techniques, including voxel-wise analysis, double inversionrecovery sequences, 7-tesla MRI, and MS spectroscopy, were published. The sensitivitiesand specificities of various AQP4-Ab tests were assessed, and the clinical characteristics of NMOpatients who did not show seropositivity for AQP4-Ab were described. The efficacies of new therapeuticsincluding plasmapheresis, several monoclonal antibodies, and other various medicineswere also evaluated. Journal of Multiple Sclerosis 5(1):7-13, 2014"

Key Words: Neuromyelitis optica, Neuromyelitis optica spectrum disorder, Pathophysiology, Clinical Trial, Diagnostic Imaging, Treatment