Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Presenting  as Cortical Encephalitis in A Patient with Crohn’s Disease Receiving Anti-Tumor  Necrosis Factor Therapy

Lee, Joo Yeon; Seok, Jin Myoung; Kim, Jee Hyun

doi:2026.17.1.7

J Mult Scler Neuroimmunol > Volume 17(1); 2026 > Article

Case Report

Journal of Multiple Sclerosis and Neuroimmunology 2026;17(1):7-10.
DOI: https://doi.org/10.59578/jmsni.2026.17.1.7-10 Published online June 30, 2026.

항종양괴사인자 치료 중인 크론병 환자에서 대뇌피질뇌염으로 발현한 MOG항체 연관 질환

이주연¹, 석진명², 김지현²

^¹이화여자대학교 의과대학 이대목동병원 신경과
^²이화여자대학교 의과대학 이대서울병원 신경과

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Presenting as Cortical Encephalitis in A Patient with Crohn’s Disease Receiving Anti-Tumor Necrosis Factor Therapy

Joo Yeon Lee¹, Jin Myoung Seok², Jee Hyun Kim²

¹Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea
²Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea

Correspondence: Jin Myoung Seok, Tel: +82-2-6986-1635,
Email: jm.seok@ewha.ac.kr

Received: 28 May 2026 • Revised: 9 June 2026 • Accepted: 22 June 2026

Abstract

A 28-year-old man with Crohn’s disease receiving infliximab developed focal motor seizures with unilateral cortical hyperintensity on brain magnetic resonance imaging and serum myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G positivity, consistent with MOG antibody-associated disease (MOGAD) presenting as cortical encephalitis. His symptoms improved after corticosteroid therapy. MOGAD should be considered in patients receiving anti-tumor necrosis factor therapy who develop new-onset cortical manifestations.

Key Words: Crohn disease, Infliximab, Myelin-oligodendrocyte glycoprotein