2017 Revised McDonald Criteria for Multiple Sclerosis

Lee, Seon-Ah; Kim, Jee-Eun

J Mult Scler > Volume 9(2); 2018 > Article

Review Article

Journal of Multiple Sclerosis 2018;9(2):15-20.
Published online September 1, 2018.

2017년도 개정 McDonald 다발성경화증 진단기준

이선아¹, 김지은²

^¹서울의료원 의학연구소
^²서울의료원 신경과

2017 Revised McDonald Criteria for Multiple Sclerosis

Seon-Ah Lee¹, Jee-Eun Kim²

¹Research Institute, Seoul Medical Center, Seoul, Korea
²Department of Neurology, Seoul Medical Center, Seoul, Korea

Abstract

"Diagnostic criteria for multiple sclerosis continue to evolve with clinical, laboratory and technical advancements. Although the 2010 McDonald criteria are well applicable in clinical and research settings,recent efforts were made by the International Panel on Diagnosis of Multiple Sclerosis to simplifyand improve diagnosis of the disease in the early phase without reducing specificity. In the 2017McDonald criteria, three important modifications were made. First, a positive oligoclonal band in cerebrospinalfluid can be substituted for dissemination in time in patients presenting with the typicalclinically isolated syndrome and go well with dissemination in space criteria. Second, symptomaticMRI lesions can also be considered for dissemination in space or time. Third, cortical lesions on MRIcan be regarded as juxtacortical lesions for dissemination in space. Validation of the 2017 McDonaldcriteria in a diverse population is needed, and incorporation of evidence of optic nerve involvementor other biomarkers into multiple sclerosis criteria will require further investigation. Journal of Multiple Sclerosis 9(2):15-20, 2018"

Key Words: Diagnosis, Multiple sclerosis