Multiple Sclerosis and Monoclonal Antibody

Park, Su-Yeon; Park, Su-Yeon; Sung, Jung-Joon; Sung, Jung-Joon

J Mult Scler > Volume 3(2); 2012 > Article

Review Article

Journal of Multiple Sclerosis 2012;3(2):47-50.
Published online September 1, 2012.

다발성경화증과 단클론항체

박수연, 박수연, 성정준, 성정준

서울대학교병원 신경과
서울대학교병원 신경과

Multiple Sclerosis and Monoclonal Antibody

Su-Yeon Park, Su-Yeon Park, Jung-Joon Sung, Jung-Joon Sung

Department of Neurology, Seoul National University Hospital, Seoul, Korea
Department of Neurology, Seoul National University Hospital, Seoul, Korea

Abstract

"Multiple sclerosis is an inflammatory demyelinating disease of central nervous system caused by various autoimmune responses. Recent studies about pathophysiology of multiple sclerosis haveled to development of various disease modifying drugs. Monoclonal antibodies are commonly usedin treatment of autoimmune diseases and several cancers, but recently diverse clinical researchesinvestigated about its effectiveness in multiple sclerosis. Monoclonal antibody belongs to targetedtherapy with highly specific immune-modulatory property, so it may offer considerable effect overother conventional therapies for multiple sclerosis. Further studies are needed about therapeutic effectand safety of monoclonal antibodies in multiple sclerosis. Journal of Multiple Sclerosis 3(2):47-50, 2012"

Key Words: Multiple sclerosis, Monoclonal antibodies, Targeted therapy