Primary Central Nervous System Lymphoma Initially Misdiagnosed as Tumefactive Demyelinating Disease

Kim, Jiah; Kim, Yong-Sung; Park, So-Hyun; Yoo, Il-Han; Ahn, Suk-Won

J Mult Scler > Volume 10(1); 2019 > Article

Case Report

Journal of Multiple Sclerosis 2019;10(1):18-4.
Published online March 1, 2019.

종괴 형성 탈수초질환으로 초기 오진된 일차성 중추신경계 림프종

김지아, 김용성, 박소현, 유일한, 안석원

중앙대학교 의과대학 중앙대학교병원 신경과

Primary Central Nervous System Lymphoma Initially Misdiagnosed as Tumefactive Demyelinating Disease

Jiah Kim, Yong-Sung Kim, So-Hyun Park, Il-Han Yoo, Suk-Won Ahn

Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea

Abstract

"Lesions of primary central nervous system lymphoma (PCNSL) are frequently misdiagnosed on brain MRI as tumefactive demyelinating diseases, such as multiple sclerosis (MS) or neuromyelitis optica (NMO). Biopsy may fail to detect tumor cells and indicate only inflammatory cell infiltration with demyelination. Both PCNSL and demyelinating diseases respond to corticosteroid therapy or improve spontaneously. Herein, we describe a patient with a PCNSL who was first diagnosed with tumefactive MS or NMO based on initial brain MRI and biopsy findings. Journal of Multiple Sclerosis 10(1):18-21, 2019"

Key Words: Primary CNS lymphoma, Neuromyelitis optica, Multiple sclerosis