Neuromyelitis Optica Spectrum Disorder without Anti-AQP4 Antibody after Treatment of Latent Syphilis

Lee, Ju Heon; Lim, Young Gi; ,; Ham, Joo Yeon; Song, Hee-Jung; Lee, Ae Young; Sohn, Eun Hee

J Mult Scler > Volume 7(2); 2016 > Article

Case Report

Journal of Multiple Sclerosis 2016;7(2):59-62.
Published online September 1, 2016.

잠복매독 이후 발생한 항 AQP4 항체 음성 시신경척수염스펙 트럼질환 증례

이주헌, 임영기, 김용수, 함주연, 송희정, 이애영, 손은희

충남대학교 의과대학 신경과학교실

Neuromyelitis Optica Spectrum Disorder without Anti-AQP4 Antibody after Treatment of Latent Syphilis

Ju Heon Lee, Young Gi Lim, Young Gi Lim, Joo Yeon Ham, Hee-Jung Song, Ae Young Lee, Eun Hee Sohn

Department of Neurology, Chungnam National University, College of Medicine, Daejeon, Korea

Abstract

"Neuromyelitis optica spectrum disorder (NMOSD) is characterized by optic neuritis, longitudinally extensive transverse myelitis (LETM), or area postrema syndrome. Chronic infection such as humanimmunodeficiency virus or syphilis is one of the red flags of NMOSD. We report a case presentingwith LETM and area postrema lesion following treatment of latent syphilis. Syphilis might be one ofthe causes of post-infectious NMOSD as well as one of causes of chronic CNS infection. Journal of Multiple Sclerosis 7(2):59-62, 2016"

Key Words: Neuromyelitis optica, Neurosyphilis, Syphilis