Myelin Oligodendrocyte Glycoprotein Immunoglobulin-G Associated Central Nervous System Inflammatory Disorder

Ryu, Seong Geun; Park, Min Su

J Mult Scler > Volume 9(1); 2018 > Article

Review Article

Journal of Multiple Sclerosis 2018;9(1):1-6.
Published online March 1, 2018.

수초희소돌기아교세포당단백질 항체 연관 중추신경염증질환

류성근, 박민수

영남대학교 의과대학 신경과학교실

Myelin Oligodendrocyte Glycoprotein Immunoglobulin-G Associated Central Nervous System Inflammatory Disorder

Seong Geun Ryu, Min Su Park

Department of Neurology, Yeungnam University College of Medicine, Daegu, Korea

Abstract

"Autoantibody against myelin oligodendrocyte glycoprotein (MOG) has been recently recognized as a new inflammatory disease entity distinct from multiple sclerosis (MS) and aquaporin-4 (AQP4) antibodypositive neuromyelitis optica spectrum disorder (NMOSD). MOG autoantibody may cause oligodendrocytedamage and myelin dysfunction without astrocytopathy. MOG-immunoglobulin G(IgG) is detected in 4-10% of central nervous system (CNS) inflammatory demyelinating disordersthat include MS, NMOSD, acute disseminated encephalomyelitis (ADEM), idiopathic optic neuritisand idiopathic acute transverse myelitis. MOG-IgG disease affects female slightly more than male.The most common clinical phenotype is optic neuritis followed by myelitis, brainstem symptoms,ADEM like presentation and multifocal involvement. About 50-80% of MOG-IgG disease have relapsingdisease course and relapsing optic neuritis is the most common clinical syndrome. Acutetreatment and long term maintenance therapy are needed in MOG-IgG disease. Prognosis inMOG-IgG disease has more favorable outcome than AQP4 antibody positive NMOSD.Journal of Multiple Sclerosis 9(1):1-6, 2018"

Key Words: Myelin oligodendrocyte glycoprotein, Neuromyelitis optica spectrum disorder, Aquaporin 4